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GLUT1 is constitutively expressed on the cardiomyocyte plasma membrane and is responsible for basal glucose uptake, whereas GLUT4 is predominantly stored in intracellular vesicles and translocates to the plasma membrane in response to insulin stimulation or increased mechanical workload, thereby enhancing glucose uptake capacity (58)

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For instance, prominently stimulated expression of the egr-1 gene includes cytokine and growth factor generation, and early extracellular matrix (collagen) formation, and blood vessel function and its repressor naB2 (55), very likely provides a particular feedback-process consistently responsible for the simultaneous healing of two different tissues and fistulas healing (10-12)